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Endotoxin Enhancement of Plasma Cell Tumor Development in Mice Given Injections of Mineral Oil¹

Research Institute of the Hospital for Joint Diseases, and Medical Center, Mount Sinai School of Medicine, New York, New York 10035 [C. B., G. S., V. P. H.]

Bacterial endotoxins administered to BALB/c mice given i.p. mineral oil cause an increased incidence of plasma cell tumors, compared with mice given either oil or antigens alone, or oil plus antigen other than endotoxin. Endotoxin in ng doses was more effective than in µg doses.

¹ Supported by USPHS Grant CA 14194, Grant CA 12635 from the National Cancer Institute, and Grant RR 05589 from General Research Support Program Division of Research Resources.

² Present address: Schering-Plough Corporation, Bloomfield, N. J.

³ To whom requests for reprints should be addressed, at 1919 Madison Ave., New York, N. Y. 10035.

Received 1/ 7/76. Accepted 3/ 1/76.