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Decreased Lymphocyte Adenosine Deaminase Activity in Tumor Patients¹

Department of Biochemistry, Wayne State University School of Medicine, Detroit 48201 [J. U., R. M. J., J. J. L.], and Division of Oncology, Henry Ford Hospital, Detroit, Michigan 48201 [R. T.]

Adenosine deaminase has been measured in the lymphocytes of individuals with various types of solid tumors. The mean activity was found to be significantly lower when compared with control individuals of a similar age.

¹ Supported by American Cancer Society Grant IM 68A, NIH Grants AI 11923 and AI 11013, and a grant from Henry Ford Hospital Research Committee.

Received 10/16/75. Accepted 3/ 9/76.