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Tumor-associated Thymidine Kinase in the Sera of Rats with Transplanted Hepatomas¹

Department of Nuclear Medicine, Veterans Administration Hospital, San Diego 92161 [A. T.], and Departments of Nuclear Medicine [A. T.] and Medicine [E. G. H., O. W. J.], University of California, San Diego, La Jolla, California 92093

A cytoplasmic form of thymidine kinase was detected in sera from rats bearing Morris hepatoma 7777. Polyacrylamide electrophoretic properties demonstrate similarity between the serum enzyme and the same enzyme extracted from hepatoma tissue. This form of thymidine kinase has also been described in normal human fetal tissue and a variety of human tumor cells. The results suggest that serum isoenzymes of thymidine kinase may be a useful adjunctive test for the presence of certain types of malignant tumors.

¹ This research was supported in part by an institutional grant from the American Cancer Society (IN93D) and a grant from the NIH (CA13639).

² To whom requests for reprints should be addressed, at Department of Nuclear Medicine (172), Veterans Administration Hospital, 3350 La Jolla Village Drive, San Diego, Calif. 92161

Received 12/ 2/75. Accepted 2/20/76.