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Alterations in the Transcriptional Capacity of Hepatic DNA-dependent RNA Polymerase I and II by N-Hydroxy-2-acetylaminofluorene¹

Department of Pharmacology, Emory University, Atlanta, Georgia 30322

Using hepatic RNA polymerases I and II, acetylaminofluorene modification of DNA in vitro results in reduction of RNA elongation but not in an altered frequency of incorporation of [³²P]ribonucleotides. In contrast, in vivo modification of RNA polymerases by a single dose of N-2-hydroxy-2-acetylaminofluorene results in an alteration of their capacity for transcribing a normal RNA product but does not affect the product size transcribed from normal or carcinogen-modified templates.

¹ Publication 1334 of the Division of Basic Health Sciences, Emory University. This investigation was supported by Grant 14162, awarded by the National Cancer Institute, Department of Health, Education and Welfare.

Received 1/ 2/76. Accepted 3/22/76.