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Effect of Avitaminosis A and Hypervitaminosis A on Urinary Bladder Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-Thiazolyl]formamide¹

Department of Human Oncology, University of Wisconsin Center for Health Sciences, Madison, Wisconsin 53706

³ To whom requests for reprints should be addressed.

The effect of vitamin A deficiency and hypervitaminosis A on the urothelial carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) was determined in female weanling Sprague-Dawley rats. Vitamin A deficiency resulted in squamous metaplasia of the urinary bladder and high incidences of cystitis, ureteritis, and pyelonephritis. Administration of FANFT to vitamin A-deficient rats appeared to accelerate the carcinogenic process, with earlier appearance of urinary bladder tumors and the development of ureteral and renal pelvic carcinomas. Most of these tumors were squamous cell, occasionally with transitional cell foci. Hypervitaminosis A prevented the appearance of squamous metaplasia and squamous cell neoplasia in rats fed FANFT, but it did not inhibit the formation of transitional cell hyperplasia or neoplasia in comparison to rats receiving normal levels of vitamin A and FANFT.

¹ Supported in part by USPHS Research Grants CA 10017, CA 11946, and CA 14520 from the National Cancer Institute. A preliminary report of this work was presented (3).

² Medical Scientist Trainee of the National Institute of General Medical Sciences, USPHS, Grant GM-01932. Present address: Department of Pathology, St. Vincent Hospital, Worcester, Mass. 01610.

Received 1/16/76. Accepted 4/ 8/76.