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Chemically Induced Smooth Muscle Tumors of the Mouse Urinary Bladder¹

O. Bulay and H. K. Urman

Department of Pathology, St. Vincent Hospital, and Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01610 [J. B. J., S. M. C., M. A., G. H. F.], and Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105 [O. B., H. K. U.]

Occasional submucosal tumors of indeterminate origin and without definite connection to the overlying mucosa have been reported in mice given various carcinogenic agents. Two Swiss mice fed niridazole developed such tumors. Electron microscopy of 1 of the tumors revealed thin myofilaments with oval dense bodies, marginal dense plaques, and gap junctions, identifying the tumor as originating from smooth muscle cells. No desmosomes, tonofilaments, secretory granules, striated muscle, or collagen were present in the tumor cells. Since the biology of these lesions is unknown, classification as benign or malignant cannot be made at this time. Their recognition is important in evaluating possible bladder carcinogens in mice.

¹ Supported in part by Department of Health, Education and Welfare General Research Support Grant 1-501-RR-05660-01, USPHS Research Grant CA-15945 from the National Cancer Institute through the National Bladder Cancer Project, and by USPHS Contract NO1-CP-33278 from the National Cancer Institute, NIH.

Received 1/ 5/76. Accepted 3/26/76.

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