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Precursor Lesions of Bronchogenic Carcinoma¹

Cancer and Toxicology Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Clinical investigations and experimental studies concerned with preneoplastic and early neoplastic lesions in the respiratory tract are discussed. The occurrence of preinvasive states of carcinoma in the bronchus has been recognized for over 20 years. Histopathological and cytological studies suggest that it might become possible to identify even earlier preneoplastic precursor lesions provided the proper tissue or cell markers can be found. Experimental models that should be useful in establishing a better understanding of the evolution of the neoplastic diseases in the respiratory tract are now available.

¹ Presented at the Conference "Early Lesions and the Development of Epithelial Cancer," October 21 to 23, 1975, Bethesda, Md. Research jointly supported by the Carcinogenesis Program of the National Cancer Institute and the U. S. Energy Research and Development Administration under contract with Union Carbide Corporation.