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Differential Inhibition of Embryonic Cell Aggregation by Cultured Human Cells with "Malignant" or "Normal" Characteristics¹

Departments of Experimental Pathology [D. E. M., E. M.] and Immunology and Immunochemistry Research [J. M.], Roswell Park Memorial Institute, Buffalo, New York 14263

The effect that cultured human cells have on chick embryonic neural retina cell aggregation was examined. Different types of human cultured cells inhibited aggregation of chick neural retinal cells to different degrees when mixed at a human cell:retina cell ratio of 1:60. It appeared from the eleven cell lines studied that cells with "malignant" characteristics inhibited retinal cell aggregation to a greater extent than those with more "normal" characteristics. The assay could be used as a further test for abnormality of cell types and also as a method for studying the interactions of malignant cells with cultured cells.

¹ This work was supported by NIH Grants CA 14370, CA 14405, and CA 14413.

² To whom requests for reprints should be addressed, at the Department of Experimental Pathology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, N. Y. 14263.

Received 7/14/75. Accepted 4/20/76.