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Application of a Galactosidase Immunosorbent Test to Carcinoembryonic Antigen in Plasma¹

Laboratory of Experimental Immunology and Biophysics, The Miriam Hospital-Brown University, Providence, Rhode Island 02906

The galactosidase immunosorbent test for carcinoembryonic antigen is simple to perform, uses stable reagents, does not require radioactive reagents, and is adaptable to large numbers of samples. Concentration of carcinoembryonic antigen in sera or plasma was determined by the galactosidase immunosorbent test and by the Egan-Todd double antibody assay (93% agreement), indirect Z-gel (83% agreement), and direct Z-gel assay (p₈ = 0.97). The galactosidase immunosorbent test has potential as a clinically useful nonisotopic assay for carcinoembryonic antigen.

¹ This investigation was supported by USPHS Grant CA-15261 from the National Cancer Institute through the National Large Bowel Cancer Project.

² To whom requests for reprints should be addressed.

Received 3/18/76. Accepted 4/30/76.