This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pour, P. Articles by Mohr, U. Search for Related Content PubMed PubMed Citation Articles by Pour, P. Articles by Mohr, U.

N-Nitroso-bis(2-acetoxypropyl)amine as a Further Pancreatic Carcinogen in Syrian Golden Hamsters¹

Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105 [P. P., J. A., R. G., R. K.]; Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Heidelberg, West Germany [F. K.]; and Abteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover, Hannover, Germany [U. M.]

N-Nitroso-bis(2-acetoxypropyl)amine, a possible ß metabolite of N-nitroso-di-n-propylamine, was shown to be a potent carcinogen in the Syrian golden hamster. After a single s.c. treatment, the pancreas was the most affected organ, followed by the liver, respiratory tract, and kidneys. However, repeated application resulted in a higher incidence of neoplasms of the respiratory tract than of the pancreas and kidneys. The effect of N-nitroso-bis(2-acetoxypropyl)amine on toxicity, target tissues, and carcinogenicity was similar to that of N-nitroso-bis(2-hydroxypropyl)amine. The assumption that these two compounds may have similar metabolic pathways was confirmed; N-nitrosobis(2-acetoxypropyl)amine was readily deesterified to N-nitroso-bis(2-hydroxypropyl)amine in vivo and in vitro.

¹ Supported by USPHS Contract NO1 CP33278 from the National Cancer Institute, NIH.

² To whom requests for reprints should be addressed, at Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42nd Street and Dewey Avenue, Omaha, Nebr. 68105.

Received 2/ 5/76. Accepted 4/29/76.