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Combined Adriamycin and Hyperthermia Treatment of a Murine Mammary Carcinoma in Vivo¹

Institute of Cancer Research, Radiumstationen, DK-8000 Aarhus C. Denmark

A study was made of the effect of combined adriamycin and hyperthermic treatment in a solid mouse mammary carcinoma in vivo.

This study demonstrated: (a) that, when given separately, adriamycin and hyperthermia enhance the destruction of a solid mouse mammary carcinoma in vivo; hyperthermia alone in high doses may even cause long-time survival; (b) that the combination of adriamycin and local hyperthermia (40.5–42.5°) greatly increases tumor destruction and, in a number of cases, causes initial and long-time regression; (c) that whole-body hyperthermia in combination with adriamycin gives a significant delay in tumor growth as compared with the controls, but not to the same degree as the local combined therapy; and (d) that treatment with local hyperthermia and adriamycin gives a pronounced decrease in the lethal toxicity of adriamycin.

The effect of adriamycin and heat treatment may be due to hyperthermic cell destruction in the central area of the solid tumor, together with a synergistic effect of heat and adriamycin on the proliferating peripheral tumor cells.

Furthermore, local heat application may increase the adriamycin concentration in the heated tumor area, which causes a high destructive effect and a less toxic influence on the nonheated normal tissue.

¹ Sponsored by the Danish Cancer Society.

Received 2/17/76. Accepted 5/25/76.