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Ultrastructural and Biochemical Changes in Cultured Human Malignant Melanoma Cells after Heterotransplantation into Nude Mice¹

Unité 119 de l'Institut National de la Santé et de la Recherche Médicale, 27, Boulevard Lei Roure, 13009 Marseille, France

Cells from three lines of cultured human malignant melanomas were heterotransplanted into nude mice and then recultured. The shape of the cells, the aspect of the melanosomes, and the content of 5-S-cysteinyldopa showed pronounced changes induced by the transplantation. Such results indicate that this experimental model should be used with great caution. A relationship was found between the shape of the melanosomes and the content of 5-S-cysteinyldopa in the cells.

¹ Supported by Contract A.T.P. 23 from the Institut National de la Santé et de la Recherche Médicale, and by grants from the Swedish Cancer Society, Swedish Medical Research Council, the John and Augusta Persson Foundation for Scientific Medical Research, and the Walter, Ellen and Lennart Hesselman Foundation for Scientific Research.

² To whom requests for reprints should be addressed.

³ Present address: Department of Electron Microscopy, Institut Gustave Roussy, Villejuif, France.

⁴ Present address: Department of Dermatology and Pharmacology, Lund, Sweden.

⁵ C. Aubert, C. LaGrange, H. Rorsman, and E. Rosengren. Catechols in Primary and Metastatic Human Malignant Melanoma Cells in Monolayer Culture. European J. Cancer, 12: 441–445, 1976.

Received 9/10/75. Accepted 4/30/76.