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Effects of the Immunosuppressive Drug Niridazole in Isogeneic and Allogeneic Mouse Tumor Systems in Vivo¹

Department of Immunopathology, The Cleveland Clinic Foundation [S. D. D., V. W. L., T. C.], and the Division of Geographic Medicine, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals [K. S. W., A. F. M.], Cleveland, Ohio 44106

In both isogeneic (Sarcoma 1 in A/JAX mice) and allogeneic (Sarcoma 180 in C57BL/6 mice) mouse tumor systems, treatment of the tumor-bearing mice with niridazole, an antiparasitic drug, known to be a potent suppressor of cell-mediated but not humoral immunity caused enhancement of metastases to regional popliteal nodes. Niridazole also inhibited tumor growth in vivo, as manifested by a significant decrease in the weight of the primary tumors. The enhancement of metastases is attributed to the suppression of cell-mediated immunity by the drug, but the mechanism of tumor-growth inhibition is not yet clear.

¹ This study has been supported by USPHS Grant AI-08163, National Cancer Institute Grant CA 13916-02, and by the Edna McConnell Clark Foundation.

Received 3/ 3/76. Accepted 5/13/76.