This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Brinster, R. L. Search for Related Content PubMed PubMed Citation Articles by Brinster, R. L.

Participation of Teratocarcinoma Cells in Mouse Embryo Development¹

Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19174

Teratocarcinoma cells (OTT 6050) from 129 SvSl C P mice were transferred into blastocysts from random-bred Swiss albino mice. The blastocysts were placed in the uteri of foster mothers and the adults resulting from these blastocysts were studied for evidence of an effect of the transferred malignant cells. Sixty adults resulted from the experiments, and one of the adult mice that had received teratocarcinoma cells in the blastocyst stage showed several stripes of agouti hair. All the adult animals received grafts of skin from animals identical to those supplying the cells. The animals that resulted from blastocysts into which cells had been transferred maintained skin grafts for a significantly longer period than did controls. These experiments indicate that the transferred malignant cells were able to establish small colonies in the embryos and that some of these cells persisted into the adult.

¹ Presented at the Symposium "Cancer and Chemistry" as part of the Fourth Conference on Embryonic and Fetal Antigens in Cancer, November 2 to 5, 1975, Charleston, S. C. This work was supported by USPHS Research Grant CA 14676 from the National Cancer Institute and Grant HD 08535 from the National Institute of Child Health and Human Development.