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Human Chorionic Gonadotropin in Human Neoplastic Cells¹

Department of Pathology [L. M. M., A. M-H.], and Department of Obstetrics and Gynecology [M. A. N.], University of Colorado Medical Center, Denver, Colorado 80220

Peroxidase-labeled antibody against the ß chain of human chorionic gonadotropin was used to demonstrate that 25 human malignant tumors contained this antigen. The antigen was localized both in the cytoplasm and on the surface of the malignant cells. Human chorionic gonadotropin may be responsible for both selective maternal immunosuppression by fetal tissue and host immunosuppression by tumors.

¹ Presented at the Symposium "Cancer and Chemistry" as part of the Fourth Conference on Embryonic and Fetal Antigens in Cancer, November 2 to 5, 1975, Charleston, S C. Supported in part by NIH Grants CA-15823 and HD-00781.

² Presenter.