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Deficiency of S-Adenosylmethionine-Homocysteine Methyltransferase Activity in Hepatoma Cells¹

Biology Division, National Cancer Center Research Institute, Tsukiji 5-1, Chuo-ku Tokyo, Japan

S-Adenosylmethionine-homocysteine methyltransferase, which catalyzes synthesis of methionine from homocysteine, with the use of S-adenosylmethionine as the methyl donor, is absent in tumor tissue such as rat ascites hepatoma and Morris hepatoma but is present in rat liver homogenate. Absence of the enzymatic activity in tumor cells is not due to the action of an inhibitor. S-Adenosylhomocysteine hydrolase, however, is present in both rat liver and hepatoma tissue.

¹ This investigation was supported in part by a grant from the Japanese Ministry of Education.

Received 11/ 5/75. Accepted 10/ 6/76.