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Influence of Adriamycin and Adriamycin-Radiation Combination on Jejunal Proliferation in the Mouse¹

Cancer Research Unit, Clinical Radiation Therapy Research Center, Division of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212

The influence of adriamycin and adriamycin-radiation combinations on posttreatment proliferative activity of the mouse jejunum was examined by measuring [³H]thymidine incorporation. Single doses of 5 or 10 mg/kg produced a transient reduction in the proliferative activity, while 1 mg/kg had little effect. After 10 mg/kg, there was a rapid decrease in the number of mitotic figures, followed by a gradial decrease in the number of and rate of DNA synthesis in S-phase cells. A compensatory epithelial hyperplasia characterized by an enlarged crypt proliferative population and shortened mitotic cycle duration was observed beginning 48 hr after treatment. Multiple doses of adriamycin totaling 10 mg/kg inhibited cell production to a greater extent than the equivalent single dose. In combination with 1000 R, adriamycin (5 mg/kg) given from 96 hr before to 72 hr after irradiation reduced the amount of postirradiation proliferation.

¹ Supported by Contract N01-437-30 from the Division of Cancer Treatment and Grant CA 10438 from the National Cancer Institute.

Received 8/12/74. Accepted 9/29/76.

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