This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Toth, B. Articles by Hoffmann, D. Search for Related Content PubMed PubMed Citation Articles by Toth, B. Articles by Hoffmann, D.

Induction of Tumors in Mice with the Herbicide Succinic Acid 2,2-Dimethylhydrazide¹

The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105 [B. T., L. W., K. P.], and Naylor Dana Institute for Disease Prevention, Division of Experimental Carcinogenesis, American Health Foundation, Valhalla, New York 10595 [I. S., D. H.]

A solution of 2% succinic acid 2,2-dimethylhydrazide was given continuously in the drinking water of 6-week-old randomly bred albino mice for the remainder of their lives. The treatment gave rise to tumors of blood vessels, lungs, and kidneys. The tumor incidences in these tissues in the controls were 6, 18, and 0%, whereas in the treated groups the corresponding tumor incidences were 73, 73, and 5%. Light microscopic examination revealed typical angiomas and angiosarcomas of blood vessels, adenomas and adenocarcinomas of lungs, and adenomas of kidneys.

The study thus demonstrates the tumorigenicity of the herbicide, succinic acid 2,2-dimethylhydrazide. Since the residues of this chemical occur in fruit, the human population is exposed to it. The environmental implication of this finding and the fact that the hydrazines as a class have tumorigenic properties are discussed.

¹ This work was supported by USPHS Contract 1 CP33278 from the National Cancer Institute, NIH. This study was presented in part at the meeting of the American Association of Pathologists, Toronto, Ontario, Canada, on March 13, 1977 (B. Toth and A. Tompa. Tumor Induction with Succinic Acid 2,2-Dimethylhydrazide, a Plant Growth Regulator. Am. J. Pathol., 86 (Part 2): 25a–26a, 1977).

Received 5/26/77. Accepted 6/27/77.