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Metabolism of Three Cyclic Nitrosamines in Sprague-Dawley Rats¹

Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

The metabolism of three cyclic nitrosamines has been studied in Sprague-Dawley rats. The compounds were nitrosopyrrolidine, nitrosohexamethyleneimine, and nitrosoheptamethyleneimine and were labeled at the carbon with ¹⁴C. At low doses (2 to 4 mg/animal) the compounds were metabolized to ¹⁴CO₂ to the extent of 77, 43, and 27%, respectively, after 24 hr. At doses closer to the 50% lethal dose of the compounds (70 to 160 mg/animal) the metabolism values were only 14, 4, and 8%, respectively, after 24 hr. The significance of these results is discussed.

¹ Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the Energy Research and Development Administration under contract with the Union Carbide Corporation.

² Present address: Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick, Md. 21701.

Received 2/22/77. Accepted 7/ 6/77.