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Factor XIII Deficiency in BALB/c Mice with Plasmacytoma¹

Hematology-Oncology Section, Department of Medicine, UCLA San Fernando Medical Program, Veterans Administration Hospital, Sepulveda, California 91343

These studies examined the fate of Factor XIII (fibrin-stabilizing factor) in mice with plasmacytoma (MOPC-300, MOPC-384, MOPC-467, and J-558). Plasma Factor XIII levels in these mice decreased progressively with tumor expansion. No plasma inhibitors of Factor XIII activity could be detected. Factor XIII was found on plasmacytoma cell membranes and in the cytoplasm of the malignant cells by immunofluorescence. The inverse relationship between tumor load and plasma Factor XIII levels suggested that the fibrinstabilizing factor was absorbed by the malignant cells.

¹ This research was supported by Veterans Administration Research Funds Grant 1577-03.

Received 3/ 3/77. Accepted 7/ 6/77.