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Characterization of L5178Y Leukemic Cells by Phagocytosis, Cytochemical Methods, and Membrane Marker Techniques¹

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4

Membrane marker techniques, endocytosis, and cytochemical methods were used to characterize L5178Y cells. L5178Y cells were found to have surface membrane immunoglobulin that typifies B-cells, and membrane receptors that are common to both B-cells and monocytes. L5178Y cells also have endocytic and enzymatic activities that are characteristic of monocytes. Thus L5178Y cells have the dual characteristics of B-cells and monocytes.

¹ Supported by the Medical Research Council of Canada.

² To whom requests for reprints should be addressed, at Department of Microbiology and Immunology, McGill University, Royal Victoria Hospital, 3775 University Street, Montreal, Quebec, Canada H3A 2B4.

Received 1/20/77. Accepted 7/ 1/77.