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Induction of Hepatic Aryl Hydrocarbon Hydroxylase in C57BL Mice by Ionizing Radiation¹

Departments of Radiology [N. P., S. C. B., J. E. H.] and Obstetrics and Gynecology (R. P.), Baylor College of Medicine, Houston 77030, and Veterans Administration Hospital, Houston, Texas 77211 [J. T., L. B. N.]

Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight hr after treatment, the animals were killed and hepatic aryl hydrocarbon hydroxylase (AHH) activity was measured by spectrophotofluorometer. A comparison of hepatic AHH activity in treated and nontreated groups of mice showed that each treated group had a significantly increased AHH induction compared with the control group. Although radiation appeared to have a dose-related effect on AHH induction, the increase with dose level was not statistically significant.

¹ Aided by Grant PDT-43 from the American Cancer Society.

² To whom requests for reprints should be addressed.

Received 3/28/77. Accepted 7/20/77.