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Immunosuppressive Effects of 3-Methylcholanthrene Given Intratracheally in Various Inbred Strains of Mice¹

Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 [R. L. L.]; Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California 92037 [M. H. B., R. A. L.]; and Microbiological Associates, Inc., Bethesda, Maryland 20016 [G. F. G., C. E. W.]

The immunosuppressive effects of 3-methylcholanthrene (MCA) given intratracheally have been shown to correlate with susceptibility of some inbred strains of mice to MCA-induced carcinogenesis. In susceptible strains of mice, C3Hf and C57BL/6, intratracheal administration of MCA resulted in profound systemic immunodepression. This effect was not observed in resistant DBA/2 mice. This immunodepressive effect correlated with the inducibility of the aryl hydrocarbon hydroxylase enzyme complex and the inducibility of pulmonary tumors by MCA.

¹ This is Publication 997 from the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, Calif. 92037. This research was supported by the Council for Tobacco Research, U. S. A., Grants CTR 766 ARI and CRT 766-B and Contracts CTR 14 and CTR 16-B.

² Present address: 508 Van Dyke Avenue, Del Mar, Calif. 92014. To whom correspondence and requests for reprints should be addressed.

Received 3/31/77. Accepted 7/22/77.

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