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Inhibition of Target Cell Mitosis as a Measure of the Cytostatic Effects of Activated Macrophages on Tumor Target Cells¹

Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301, and Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

Studies were carried out in vitro that showed that activated macrophages inhibited tumor target cells from undergoing mitosis. With the use of target cells synchronized in the mitosis phase of the cell cycle, this manifestation of macrophage-mediated cytostatic effects was preceded by the complete inhibition of target cell DNA synthesis as measured by incorporation of [³H]thymidine.

¹ Supported in part by USPHS Contract N01-CB43873 and the Nelson-Quinby Memorial Fund for Cancer Research.

² Recipient of USPHS Research Career Development Award A170931 from the National Institute of Allergy and Infectious Diseases, NIH.

³ To whom requests for reprints should be addressed, at Palo Alto Medical Research Foundation, 860 Bryant Street, Palo Alto, Calif. 94301.

Received 4/25/77. Accepted 7/22/77.