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Hepatocarcinogenic Effects of N-Nitroso-N-methylurea in Guinea Pigs¹

Occupational and Environmental Medicine, School of Public Health, University of Illinois at Medical Center, Chicago, Illinois 60680

Intragastric administration of N-nitroso-N-methylurea to strain 13 male guinea pigs, at a weekly dosage of 7.5 mg/kg for 15 weeks and then twice weekly for a subsequent 15 weeks, induced high toxicity, as evidenced by weight loss and mortality and a high incidence of malignant neoplasms, over a total observational period of 40 weeks. The neoplasms included hepatic angiosarcomas, cholangiocarcinomas, and generalized lymphoblastic lymphomas.

¹ Supported by National Cancer Institute Contract NO1-CP-65843.

Received 6/24/77. Accepted 8/10/77.