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Tissue Changes Resulting from the Injection of -Irradiated Cells into the Gynogenetic Teleost, Poecilia formosa¹

Biology Department, Brookhaven National Laboratory, Upton, New York 11973 [A. D. W., R. B. S.], and Department of Radiology, Ohio State University, Columbus, Ohio 43210 [R. W. H.]

In previous studies a clone of the gynogenetic fish, Poecilia formosa (the Amazon molly), was successfully used as a test animal to identify ultraviolet-induced damage. This work has been extended, and the fish system was used to detect damage caused by ionizing radiation. Fish cells, exposed in vitro to 250 and 500 rads, were injected into young isogenic recipients, and 9 months later the fish were examined grossly and histologically. Two of the most conspicuous changes that resulted were the development of extensive invasive thyroid hyperplasia and hypertrophy and the presence of large hemorrhages throughout the body, with an apparent reduction in the amount of hematopoietic tissue in the head kidney and spleen. We discuss the difference between the responses of the recipient fish to cells exposed to ionizing radiation and to cells exposed to ultraviolet light.

¹ Supported by Contract YOL-CP-50202 from the National Cancer Institute. Research carried out at Brookhaven National Laboratory under the auspices of the United States Energy Research and Development Administration. The experiments were started in the Biology Division of the Oak Ridge National Laboratory. By acceptance of this article, the publisher and/or recipient acknowledges the United States Government's right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper.

Received 10/28/76. Accepted 8/23/77.