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Rosette Formation and Inhibition in Cervical Dysplasia and Carcinoma in Situ¹

Departments of Pediatrics [S. S., R. B. A., A. J. N.], Gynecology and Obstetrics [B. B. B.], and Pathology [M. F. L.], Emory University School of Medicine, Atlanta, Georgia 30303

Total and early rosettes and rosette inhibition were measured in patients with cervical dysplasia and carcinoma in situ. Both total and early rosettes were significantly depressed in patients with carcinoma in situ; early rosettes were also significantly lower than were controls in women with severe dysplasia. Rosette inhibition titers were increased in most patients with moderate dysplasia and in all patients with either severe dysplasia or carcinoma in situ. Thus, the rosette inhibition test may be useful in detecting, in a precancerous state, patients at risk for cancer.

¹ This study was supported by Contract N01 CP 4-3393 within the Virus Cancer Program of the National Cancer Institute and by a grant from the Smokeless Tobacco Council.

² Present address: Department of Pediatrics, Yokohama City University School of Medicine, 3–46 Urafunecho Minamiku, Yokohama, Japan.

³ Present address: Department of Microbiology, John Curtin School of Medical Research, Australian National University, P. O. Box 334, Canberra, A. C. T. 2601, Australia.

⁴ To whom requests for reprints should be addressed, at Department of Pediatrics, Emory University School of Medicine, 69 Butler Street, S. E., Atlanta, Ga. 30303.

Received 6/ 3/77. Accepted 9/ 6/77.