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Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma¹

Departments of Developmental Therapeutics [B. B., W. H., G. S., J. S. H., L. S.] and Laboratory Medicine [J. M. T., B. D.], The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030

Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (44, 53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or near-diploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.

¹ Supported in part by Grants CA-14528, CA-05831, CA-11430, and CA-12687 from the National Cancer Institutes, NIH, Bethesda, Md. 20014.

² To whom requests for reprints should be addressed, at M. D. Anderson Hospital and Tumor Institute, Department of Developmental Therapeutics, 6723 Berther Avenue, Houston, Texas 77030.

Received 5/26/77. Accepted 9/ 6/77.