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Enhanced Induction of Immune Resistance by Concanavalin Abound L1210 Vaccine and an Immunopotentiator Prepared from Coriolus versicolor¹

Japanese Foundation for Cancer Research, Cancer Chemotherapy Center, Division of Experimental Chemotherapy, Kami-lkebukuro, 1-37-1, Toshima-ku, Tokyo 170, Japan

Combined administration of a vaccine consisting of a small number (2 x 10⁶) of L1210 murine leukemic cells treated with glutaraldehyde and concanavalin A and a protein-bound polysaccharide preparation of Coriolus versicolor induced synergistic resistance to L1210 leukemia in BALB/c x DBA/2Cr F₁ mice. This effect was dependent on the dose and timing of the administration of the protein-bound polysaccharide preparation, being most effective at the time of or 1 day after the second vaccination. Induced resistance was not cross-reactive with P388 murine leukemia, indicating specificity of resistance. This immunopotentiation by the protein-bound polysaccharide did not occur when L1210 cells treated with glutaraldehyde, but not with concanavalin A, were used as a vaccine.

¹ This research was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture, Japan, and by The Princess Takamatsu Cancer Research Fund.

Received 2/14/77. Accepted 9/ 6/77.