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Radioresistant Inhibition of Lymphoma Growth in Congenitally Athymic (Nude) Mice

Laboratory of Experimental Chemotherapy, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014

Several murine tumors were used to determine whether the phenomenon of tumor inhibition in athymic "nude" mice reported previously could be extended to other tumor systems in nude as well as conventional mice. The results with the L5MF-22 tumor line were confirmed, and similar data were obtained with the K36 leukemia of AKR mice and the LAF-17 leukemia of B10.A origin. This phenomenon of tumor inhibition has been called, tentatively, radioresistant inhibition of tumor and may be explained by one of several possibilities. The immunological origin of such tumor inhibition is supported by various observations. The data on tumor cell proliferation in spleens and liver of lethally irradiated mice were similar to previous findings on hemopoietic histocompatibility-incompatible lymphomas. Additionally, the nude mice were stronger responders against lymphoma cells than were conventional hosts. Another explanation is that the tumor inhibition is due to natural cytotoxicity.

¹ To whom requests for reprints should be addressed, at Institute of Pharmacology, University of Perugia, 06100 Perugia, Italy.

² Fellow of M. S. Puleio's Foundation, Messina, Italy.

³ Present address: Battelle Memorial Institute, Columbus, Ohio.

Received 7/26/76. Accepted 10/28/76.

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