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Effect of Hydrolyzed Formaldehyde-treated RNA on Neoplastic and Normal Human Cells¹

Departments of Molecular Biology and Molecular Virology, the University Hadassah Medical School, Jerusalem 1172, Israel

Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R—CH₂—R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.

¹ Supported in part by a grant from the National Council for Research and Development, Israel.

Received 5/28/76. Accepted 11/10/76.