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Genetic Control of Antinuclear Antibodies in Mice Infected with Rauscher Leukemia Virus¹

Laboratorie d'Immunologie et de Virologie des Tumeurs, National Institute of Health and Medical Research (INSERM), 75674 Paris CEDEX 14 [B. V., S. G.], and Laboratoire d'Immunochimie (INSERM), Centre Hayem-Hôpital Saint Louis, 75475 Paris CEDEX 10 [A. C.], France

The incidence of antinuclear antibodies after Rauscher leukemia virus inoculation was found to be significantly higher in C57BL/6 than in BALB/c mice and still greater in their F₁ hybrids. The relationships among antinuclear antibody incidence, erythroblastic disease, Rauscher leukemia virus production, and the H-2 genotypes were studied in the F₁ generation and backcrosses using different virus inocula. The results observed suggest that (a) at least two genes are involved in the control of susceptibility to Rauscher leukemia virus-induced erythroblastosis, one of them probably being H-2 linked, and that (b) a non-H-2-linked gene seems to control, at the same time, induction of antinuclear antibodies, focus-forming virus production in the spleen, and susceptibility to the disease. It can be concluded that C-type viruses play an active role in antinuclear antibody induction.

¹ This investigation was supported in part by Institut National pour la Santé et la Recherche Médicale and grants from the Délégation Génerale à la Recherche Scientifique et Technique.

² To whom requests for reprints should be addressed at Batiment Gustave Roussy—27, Rue du Faubourg Saint Jacques, 75674 Paris Cedex 14.

Received 7/20/76. Accepted 11/29/76.

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