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Cooperation of Immune Lymphoid and Reticuloendothelial Cells during Listeria monocytogenes-mediated Tumor Immunity¹

University of California, San Diego, Department of Pathology M-012, School of Medicine, La Jolla, California 92093

Listeria monocytogenes (LM) in admixture with cells from a murine, chemically induced tumor retarded local tumor development in the syngeneic host. Intra-footpad growth of 10⁴ tumor cells was equally inhibited by 4 x 10⁴ admixed LM in normal or LM-immune mice indicating that concomitant or prior immunity to LM was equally effective in suppressing tumor growth. Development of cellular immunity to viable LM was required for tumor rejection. Mice prevented from developing anti-LM immunity by inoculation of dead bacteria were also incapable of inhibiting tumor growth. Further, a functionally active reticuloendothelial system was essential for nonspecific inhibition of tumor development as temporary "paralysis" of the reticuloendothelial system by a prior injection of 10⁹ heat-killed LM reduced the effectiveness of LM-mediated tumor suppression. Histological examination of LM or LM tumor-injected sites revealted a stepwise development of LM-mediated inflammatory reaction of delayed type associated with gradual degeneration of the adjacent tumor cells.

¹ Supported by USPHS Grants CA 15240, CA 17299 and HL 19169.

Received 9/ 7/76. Accepted 12/28/76.

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