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Induction of Preneoplastic and Neoplastic Lesions in Grafted Rat Tracheas Continuously Exposed to Benzo(a)pyrene¹

Cancer and Toxicology Section, Biology Division [P. N., R. A. G., D. H. M.], and Analytical Chemistry Division [J. E. C.], Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Heterotopically transplanted rat tracheas were continuously exposed to measured amounts of benzo(a)pyrene over a period of 1 to 6 months. The cumulative doses ranged from 10 to 2490 µg. The morphological response of the tracheal epithelium was characterized by hyperplasia during the first 2 weeks, followed by atrophy. Squamous metaplasias did not appear until after 4 months of exposure; at 4 and 6 months numerous dysplastic lesions and noninvasive carcinomas resembling those seen in the airways of humans were found in the higher carcinogen dose groups. The first invasive carcinomas developed at 4 months in the groups given 1250 µg or more benzo(a)pyrene. The lowest dose tested that produced a carcinoma within the observation period of 22 months was 300 µg benzo(a)pyrene. The majority of the neoplasms were squamous cell carcinomas, although several adenocarcinomas and sarcomas also developed.

Since a variety of metaplastic and dysplastic lesions can be induced by carcinogenic polycyclic hydrocarbons in the transplanted rat tracheas, this experimental model appears to be well suited for the study of the sequential epithelial changes that lead to respiratory tract neoplasia.

¹ Research supported jointly by the National Cancer Institute and the U. S. Energy Research and Development Administration under contract with Union Carbide Corporation. By acceptance of this article, the publisher or recipient acknowledges the right of the U. S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article.

² To whom requests for reprints should be addressed, at Biology Division, Oak Ridge National Laboratory, Post Office Box Y, Oak Ridge, Tenn. 37830.

Received 5/20/76. Accepted 1/25/77.

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