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Increased Primary Cell-mediated Immunity in Culture Subsequent to Adriamycin or Daunorubicin Treatment of Spleen Donor Mice¹

Department of Experimental Therapeutics and Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263

Spleen cell populations from mice treated with Adriamycin or daunorubicin were found to develop a greater complement-independent cellular cytotoxic immune response during culture with allogeneic tumor cells than spleen cells from untreated or cyclophosphamide-treated animals. A temporal and drug dose dependence of this effect was demonstrated. The changes in spleen cell population occurring in the donor mice consequent to drug treatment were evident in the nylon wool-adherent fraction of the spleen cells. The results are consistent with the possibility that the concentration of specific progenitor or accessory cells in the spleen is increased consequent to drug treatment.

¹ This work was supported in part by USPHS Project Grant CA-15142, Contract CM-57039, and Core Grant CA-13038 from the National Cancer Institute.

Received 12/ 2/76. Accepted 3/11/77.

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