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Therapeutic Effects of 9-ß-D-Arabinofuranosyladenine and 2'-Deoxycoformycin Combinations on Intracerebral Leukemia¹

Department of Biophysical Sciences, University of Houston, Houston, Texas 77004

Drug combinations of 9-ß-D-arabinofuranosyladenine and 2'-deoxycoformycin were active in the therapy of mice with intracerebral implants of the L1210 tumor. In in vivo mouse brain adenosine deaminase studies, inhibition of 9-ß-D-arabinofuranosyladenine deamination for periods of up to 24 hr was found after a single i.p. dose of 0.002 mmole/kg.

¹ Supported by Grant CA 12327 from the National Cancer Institute, NIH, and Grant E-321 from the Robert A. Welch Foundation.

² To whom requests for reprints should be addressed.

Received 5/ 4/76. Accepted 3/24/77.