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Induction of Morphological Transformation in Mouse C3H/10T Clone 8 Cells and Chromosomal Damage in Hamster A(T₁)C1–3 Cells by Cancer Chemotherapeutic Agents¹

Division of Hematology-Oncology, Department of Medicine, Childrens Hospital, Los Angeles, California 90027

Various cancer chemotherapeutic agents including alkylating agents, antimetabolites, and antibiotics or natural products were studied for their ability to produce morphological transformation in the C3H/10T clone 8 mouse cell line and chromosomal damage in the A(T₁)C1–3 hamster cell line following a 24-hr exposure of each agent at different concentrations. Those drugs that were known to be carcinogenic in vivo also produced morphological transformation and chromosomal damage, whereas those agents that have not been shown to be carcinogenic in vivo produced neither transformation nor chromosomal lesions. The concentrations used for these studies were in general similar to those actually reached in the plasma of patients treated with these same drugs for malignant, as well as certain nonmalignant, conditions.

¹ This work was supported by Grant CA-14226 from the National Cancer Institute, NIH.

² Recipient of Career Development Award CA-70996 from the National Cancer Institute. To whom requests for reprints should be addressed.

Received 11/19/76. Accepted 4/15/77.

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