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Cell Cycle Phase Recovery from Bleomycin-induced Potentially Lethal Damage¹

Division of Cell Biology, Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas 77550

Mammalian cells treated during mitosis with the anticancer drug bleomycin cannot recover from potentially lethal damage. G₁- and S-phase cells treated in a similar manner can recover.

In synchronized G₁- and S-phase cells, and in asynchronous and nondividuing populations, the final survival values of recovered cells have always been found to be greater than 0.2. These data suggest that a certain fixed amount of recovery can occur, regardless of the degree of initial bleomycin-induced damage. The mechanism of this particular phenomenon is unknown.

¹ Supported by Grant DHEW 2 R01 CA 15397-04 from the National Cancer Institute, NIH, USPHS.

Received 3/ 4/77. Accepted 5/ 6/77.