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Effect of Somatostatin on Growth Hormone Release by MtT-F4 Rat Pituitary Tumor in Vitro¹

Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7

Fluoride-stimulated adenylate cyclase is demonstrated in isolated tumor cells of transplantable rat pituitary tumor MtT-F4 in vitro. The intracellular cyclic adenosine 3':5'-monophosphate is lowered in the cells incubated in the presence of synthetic somatostatin. Contrary to the findings reported for normal pituitary, however, the immunoreactive growth hormone release does not change when either somatostatin or phosphodiesterase inhibitors are present in the incubation medium. The presence of dibutyryl cyclic adenosine 3':5'-monophosphate (5 mM) in the incubation medium does not change the rate of growth hormone release by isolated tumor cells.

¹ Supported by the National Cancer Institute of Canada. Presented in part at the International Symposium on Hypothalamus and Endocrine Functions, Quebec City, September 1975.

Received 12/28/76. Accepted 5/13/77.