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Enhancement of X-ray-induced Transformation in C3H/10T Cells by Interferon¹

Department of Physiology, Harvard University School of Public Health, Boston, Massachusetts 02115

Interferon may enhance malignant transformation induced by X-rays in a C3H mouse embryo-derived cell line. The inhibitory effect of interferon on cell division during the proliferative phase of the expression of the transformational damage may be of importance in the understanding of this finding.

¹ Supported by Grants CA 11751 from the National Cancer Institute and ES 00002 from the National Institute for Environmental Health Sciences.

² Research fellow of the French Foreign Ministry on leave from the Institut de Recherches Scientifiques sur le Cancer, Villejuif, France. Present address: I.R.S.C., Laboratory of Viral Oncology, 7, rue Guy Mocquet, 94800 Villejuif, France.

Received 2/ 9/77. Accepted 3/30/77.