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Some Immunological Considerations Relevant to the Study of Human Bladder Cancer¹

Virginia Mason Research Center, Seattle, Washington 98101

The likelihood that immunosurveillance, concomitant immunity, and immunodepression play a role in the development and spread of neoplasms of the urinary bladder is discussed. The circumstantial evidence for the existence of concomitant immunity to bladder cancer-associated antigens is briefly reviewed, and the implications of the hypothesis of Zinkernagel and Dougherty of a genetic restriction to the cytotoxicity of T-cells for virally determined target cell antigens and of the concept of immunoregulatory cells for our understanding of the immunology of bladder carcinoma are discussed.

¹ Presented at the National Bladder Cancer Conference, November 28 to December 1, 1976, Miami Beach, Fia. Supported in part by Grant CA 19165 from the National Cancer Institute through the National Bladder Cancer Project, Virginia Mason Research Center Core Grant, and the Glaser Foundation, Edmonds, Washington.