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The Role of Intravesical Thiotepa in the Management of Superficial Bladder Cancer¹

This report describes and presents some preliminary results from a prospective clinical investigation to determine the ablative effect of thiotepa (N,N',N''-triethylene phosphoramide) on superficial low-stage bladder cancer and the effectiveness of this agent in the prevention of recurrent or new tumors. In the small group of cases studied thus far, therapeutic thiotepa has destroyed superficial cancers in 33 to 36% of the cases, about the same results as those reported by others. It is too early in the study to assess the benefit from the prophylactic use of thiotepa.

¹ This investigation was supported by the following USPHS grants from the National Cancer Institute through the National Bladder Cancer Project: CA 15490, CA 15491, CA 15492, CA 15497, CA 15933, CA 15934, CA 15937, CA 15944, CA 16886, CA 16899, and CA 17446. Presented by Warren W. Koontz, Jr.

² Principal Investigators and Member Institutions of the NBCCGA: G. R. Prout, Jr., NBCCGA Chairman, Massachusetts General Hospital, Boston, Mass. 02114; C. E. Cox, University of Tennessee, Memphis, Tenn. 38163; K. B. Cummings, Virginia Mason Research Center, Seattle, Wash. 98101; M. J. Flanagan, Rush Presbyterian-St. Luke's Medical Center, Chicago, III. 60612; G. H. Friedell, St. Vincent Hospital, Worcester, Mass. 01610; C. V. Hodges, University of Oregon, Portland, Oreg. 97201; W. W. Koontz, Jr., Medical College of Virginia, Richmond, Va. 23219; C. E. A. Merrin, Roswell Park Memorial Institute, Buffalo, N. Y. 14263; J. D. Schmidt, University of Iowa, Iowa City, Iowa 52242; R. J. Veenema, Columbia University, New York, N. Y. 10032; J. H. Warram, Harvard School of Public Health, Boston, Mass. 02115. Requests for reprints should be addressed to: Dr. George R. Prout, Jr., Massachusetts General Hospital, 32 Fruit Street, Boston, Mass. 02114.