This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Squire, R. A. Articles by Springer, S. Search for Related Content PubMed Articles by Squire, R. A. Articles by Springer, S.

Histopathological Evaluation of the Inhibition of Rat Bladder Carcinogenesis by 13-cis-Retinoic Acid¹

National Cancer Institute [R. A. S., M. B. S., C. C. B., J. M. S.] and Microbiological Associates [M. L. W., S. S.], Bethesda, Maryland 20014

An objective system for histopathological and statistical evaluation of rat bladder lesions induced by the carcinogen, N-methyl-N-nitrosourea, is described. This system has been used to measure the inhibitory effects of 13-cis-retinoic acid on the development of bladder cancer in female Wistar/Lewis rats. 13-cis-Retinoic acid caused significant inhibition of development of both preneoplastic and neoplastic lesions in bladder epithelium.

¹ Presented at the National Bladder Cancer Conference, November 28 to December 1, 1976, Miami Beach, Fla. Supported in part by Contract NO1-CP-02199 from the Division of Cancer Cause and Prevention, National Cancer Institute.

² Presenter.