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Cytogenetic and Immunoglobulin Markers of Human Leukemic B-Cell Lines¹

Roswell Park Memorial Institute, Buffalo, New York 14263

This study describes the establishment of two permanent leukemic B-cell lines (BALM-1 and -2) originating from the blood cells of a patient with a B-cell type of acute lymphoblastic leukemia. The cells of BALM-1 and -2 exhibited cell surface markers compatible with B-cell origin. The identity between the leukemic cells in vivo and those of the BALM lines was established on the basis of the karyotypic picture, including marker chromosomes 14q + and t(12;17;?) and cell surface immunoglobulins (, and µ chain determinants).

¹ Supported in part by Grants CA-14413, CA-16935, and CA-17609 from the National Cancer Institute.

Received 3/ 4/77. Accepted 6/ 2/77.

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