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Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595
The promoting effect of sodium cholate or sodium chenodeoxycholate on colon carcinogenesis was studied in female F344 germ-free and conventional rats. Both germ-free and conventional rats received intrarectal instillations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 2 weeks (total dose, 8 mg/rat) and then intrarectal doses of sodium cholate or sodium chenodeoxycholate (20 mg/rat/dose) three times a week for 46 weeks; other groups received MNNG for 2 weeks and vehicle thereafter for 46 weeks or bile acids alone for 48 weeks. Sodium cholate or sodium chenodeoxycholate increased MNNG-induced adenocarcinomas and adenomas in germ-free rats, whereas in conventional rats these bile acids induced more adenomas. Conventional rats treated with MNNG + sodium cholate or MNNG + sodium chenodeoxycholate had a higher incidence (p < 0.05) of colon tumors than did those given MNNG alone; germ-free rats that received MNNG + sodium cholate or MNNG + sodium chenodeoxycholate had a higher but not significant (p > 0.05) frequency of colon tumors than did those given MNNG alone. No tumors were detected in the colons of germ-free and conventional rats given sodium cholate or sodium chenodeoxycholate alone. It is concluded that sodium cholate or sodium chenodeoxycholate had a promoting effect in colon carcinogenesis in rats evoked by MNNG.
1 Supported by USPHS Contract CP-33208 from the National Cancer Institute.
Received 4/ 7/77. Accepted 6/13/77.
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