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Repair following Combined X-ray and Heat at 41° in Plateau-Phase Mammalian Cells¹

Department of Radiation Therapy, Harvard Medical School, Joint Center for Radiation Therapy, Boston, Massachusetts 02115

Plateau-phase V79 Chinese hamster cells maintained at 37° following X-irradiation demonstrated both sublethal damage repair and potentially lethal damage repair. When cells were kept at 41° for 1 hr following irradiation, no sublethal damage repair was seen. In contrast, irradiated cells maintained at 41° for 1 hr and then returned to 37° were capable of repairing both sublethal and potentially lethal radiation damage; hyperthermic (41°) inhibition of radiation damage repair was reversible. Repair was similar for cells heated before or after irradiation. The extent of sublethal damage repair (as measured by recovery ratios and quasithreshold doses) and potentially lethal damage repair (as measured by recovery ratios and dose-modifying factors) was similar following combined heat and X-ray treatment and following X-ray treatment alone.

¹ Supported by USPHS Grant CA-12662 and Training Grant CA-05237 from the National Cancer Institute, NIH.

² Present address: Department of Therapeutic Radiology, Rush-Presbyterian, St. Luke's Medical Center, Chicago, Ill. 60612.

Received 3/14/77. Accepted 6/16/77.