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Lack of Cross-resistance between Certain Platinum Coordination Compounds in Mouse Leukemia¹

Memorial Sloan-Kettering Cancer Center, New York, New York 10021

Two congeners of cis-platinum diamminodichloride, 1,2-diamminocyclohexlplatinum malonate (NSC 224964) and 1,2-cyclohexyldiamminoplatinum sulfate (NSC 250427), show approximately equal inhibitory activity in vitro against leukemia L1210 and a line of L1210 (L1210/PDD) that has developed resistance to cis-platinum diamminodichloride. These compounds are also active against L1210/PDD in vivo. These observations suggest that they be tried clinically in patients whose disease has become resistant to cis-platinum diamminodichloride.

¹ Supported by Grants 05826, 07848, and 18856 from the National Cancer Institute; The American Cancer Society Laurens Hammond Memorial CH-27S; and the Hearst Foundation.

Received 6/15/77. Accepted 7/ 6/77.