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Mutagenicity of Diallate, Sulfallate, and Triallate and Relationship between Structure and Mutagenic Effects of Carbamates Used Widely in Agriculture¹

II Cattedra di Chimica Biologica, II Facoltà di Medicina e Chirurgia, University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy

In an investigation of the mutagenic properties of 20 carbamate herbicides and fungicides by use of the Salmonella/microsome mutagenicity test as developed by Ames et al. (Mutation Res., 31: 347–364, 1975), we have found that three thiocarbamate compounds, diallate, sulfallate and triallate, are mutagenic in the presence of a liver microsomal fraction on strains TA1535 and TA100. This indicates that the metabolic products of these thiocarbamates are causing base-pair substitutions. Since the 2-chloro-allyl group is common to the three mutagenic compounds but is not common to the 17 nonmutagenic compounds, a metabolic derivative of this group is probably responsible for the mutagenic activity.

¹ Supported by Ministero della Sanità, Rome, Italy.

² Supported by the International Cancer Research Data Bank Program, National Cancer Institute, NIH, under Contract NO1-CO-65341 with the International Union Against Cancer.

Received 6/20/77. Accepted 9/27/77.

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