This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Evans, W. H. Articles by Smith, G. H. Search for Related Content PubMed PubMed Citation Articles by Evans, W. H. Articles by Smith, G. H.

Transplantable Granulocytic Leukemia In Strain 13 Guinea Pigs¹

Laboratories of Biochemistry [W. H. E., M. G. M., S. R. H.] and Molecular Biology [G. H. S.], National Cancer Institute, NIH, Bethesda, Maryland 20014, and Frederick Cancer Research Center, Frederick, Maryland 21701 [C. K. H.]

The occurrence of a granulocytic leukemia in 1 of 40 female strain 13/N guinea pigs given N-nitroso-N-butylurea continuously in their drinking water for 21 weeks is reported here. This leukemia has been successfully transplanted in this guinea pig strain for 13 transplant generations by i.p. inoculation of leukemic blood or marrow cells. Macroscopically and microscopically, this leukemia resembles the chronic myelogenous form in humans. Histochemical studies showed, however, that unlike the human leukemic cells those in the leukemic guinea pigs are alkaline phosphatase positive. Electron microscopic studies of the guinea pig leukemic cells revealed the presence of numerous intracisternal A-type particles that are not found in corresponding normal leukocytes.

¹ Supported in part under Contract 1-CO-25423 from the NIH to Litton Bionetics, Inc.

Received 5/31/77. Accepted 10/17/77.