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Carcinoma of the Prostate in Irradiated Parabiotic Rats¹

Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts 02215

Twelve hundred fifty-two pairs of male NEDH rats were parabiosed, one partner received a single dose of 1000 R X-radiation, and the other rat was shielded with lead. Eleven hundred twenty pairs survived over 200 days and constitute the basis of this report. Twenty-five of the irradiated partners developed malignant tumors of the prostate, 19 of which were adenocarcinomas. One adenocarcinoma appeared in the shielded partners and one in a control group of 586 parabiosed and single rats. The long-term effect of a single dose of 1000 R whole-body X-radiation is weakly carcinogenic for the rat prostate.

¹ Supported by Biomedical Research Support Grant RR 05591 from the Division of Research Resources, Department of Health, Education and Welfare, and by United States Energy Research and Development Administration Contract EY-76-S-3017 A001 with the New England Deaconess Hospital. This is Article 608 from the Cancer Research Institute of the New England Deaconess Hospital.

Received 7/25/77. Accepted 10/17/77.